This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the February 2007 issue of Molecular Cancer Therapeutics.
The molecular focus of this report was on nuclear factor ΚB (NF- ΚB), an anti-apoptotic transcriptional factor that is constitutively activated in AICAP cell lines. The scientists showed that SVT inhibited growth of AICAP cells lines PC-3 and DU145 with IC50's of 1.7 and 1.8ug/mL, respectively. This exceeded the IC50 in LNCaP, androgen-sensitive cells (9.1ug/mL). With increasing concentrations of SVT, the number of cells distributed in the S phase of the cell cycle decreased significantly compare with cells in other phases.
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